Atropine Blockade of Nerve‐mediated Stimulation of the Human Detrusor
- 1 August 1985
- journal article
- Published by Wiley in British Journal of Urology
- Vol. 57 (4) , 418-421
- https://doi.org/10.1111/j.1464-410x.1985.tb06301.x
Abstract
Summary— The effect of atropine on the isometric contractile response of isolated human detrusor muscle strips to electrical field stimulation has been studied. A 94.1 % reduction in the response in the presence of tetrodotoxin demonstrated the neuronal nature of the stimulus. Atropine caused a 92.7% inhibition of the response. It was concluded that the nerve‐mediated stimulus in human detrusor is cholinergic in nature and that “atropine resistance” does not occur in man.Keywords
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