Palladium Catalyzed Bispyrimidine Thioether Synthesis
- 1 October 1999
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1999 (10) , 1579-1581
- https://doi.org/10.1055/s-1999-2910
Abstract
The synthesis of sulfur-bridged bispyrimidines via coupling of a halopyrimidine and pyrimidine thiolate anion has been explored utilizing a palladium catalyzed cross coupling reaction. Several reaction parameters including stoichiometry and choice of solvent have been optimized. These reaction conditions have allowed for the preparation of a wide range of functionalized bispyrimidines.Keywords
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