Ventricular volume and cognitive deficit: a computed tomographic study.

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Abstract
A group of 35 patients with presumptive diagnosis of Alzheimer disease and 29 normal volunteer spouse controls, all > 60 yr old, underwent medical and neurologic evaluation, an extensive psychometric battery and CT [computed tomography] scanning. CT ventricular volume was derived for each CT section by algorithm summation of the number of pixels within a user-defined CSF range. Composite ventricular volume for each patient, obtained by summation of the individual section ventricular volumes, was corrected for brain size by dividing, by the sum of the 5 largest brain section volumes. For the normal group, composite ventricular volume thus derived was 5.2% and for the impaired group 7.5%; the 44% difference was significant (P < 0.009). Increasing ventricular volume was significantly associated with increasing severity of cognitive impairment (P < 0.05).

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