Effector Functions of Antiaquaporin‐4 Autoantibodies in Neuromyelitis Optica
- 1 September 2009
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1173 (1) , 478-486
- https://doi.org/10.1111/j.1749-6632.2009.04871.x
Abstract
NMO-IgG autoantibody is now considered a useful serum biomarker of neuromyelitis optica (NMO). A series of clinical and pathological observations suggest that NMO-IgG may play a central role in NMO physiopathology. Although the exact role and function of NMO-IgG in vivo remain to be determined, recent reports suggest that this antibody that targets the aquaporin-4 (AQP-4) water channel expressed by astrocytes is able to destabilize the blood-brain barrier and contribute to astrocyte and oligodendrocyte damage. This review summarizes the latest molecular effector functions attributed to the NMO-IgG/anti-AQP4 antibody and discusses their potential role in NMO pathology.Keywords
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