Influence of genetic variables on means, variances, and covariances in behavioral responses to toxicological and pharmacological substances
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 5 (1) , 145-156
- https://doi.org/10.1080/15287397909529733
Abstract
Inbred strains and F 1 generations provide strong experimental control in toxicological studies by virtue of the relative stability of their means. Their variances do not always conform to simple expectations, with respect either to each other or to segregating populations. For the evaluation of covariances or correlations, populations of choice are genetically segregating ones. A genetic approach of demonstrated power but as yet limited application to toxicological problems is that of selective breeding, a procedure by which lines of animals can be developed to precise specifications.Keywords
This publication has 2 references indexed in Scilit:
- PharmacogeneticsPublished by Springer Nature ,1977
- Genetic factors in alcohol preference of laboratory mice.Journal of Comparative and Physiological Psychology, 1961