Einfluß von Glycylpressin auf den Ösophagusvarizendruck bei Patienten mit Leberzirrhose und vorangegangener Varizenblutung

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Abstract
In 15 patients with the history of bleeding from esophageal varices, confirmed cirrhosis of the liver (Child A) and esophageal varices (grade II, 2; grade III, 11; and grade IV, 2 patients) esophageal intravariceal pressures were endoscopically measured before and 10 min after intravenous administration of 1 mg glycylpressin. Pressures fell in the patients without previous sclerotherapy from 21.8 .+-. 2.8 to 19.0 .+-. 1.9 mm Hg (not significant), in those previously sclerosed from 18.0 .+-. 1.4 to 14.5 .+-. 1.0 mm Hg (P < 0.05). In two of the non-sclerosed patients and one after sclerotherapy no change of pressure was recorded. The results indicate that glycylpressin has a relatively minor and uncertain effect on esophageal intravariceal pressure. In view of the possible side effects of the drug the indications for its use should be carefully weighed.