Effect of Estrone and Estriol on Salivary Glands and Dental Caries In Female Rats.

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Abstract
Female rats were fed a cariogenic diet beginning at 23 days of age and were given daily subcutaneous injections of either 0. 2 mg estrone or 0. 5 mg estriol for 6 wks. to determine the effect of these hormones on salivary glands and dental caries. These hormones caused a decrease in absolute weight but an increase in the organ body weight ratio of either the submandibular or parotid gland; the number and diameter of the submandibular granular tubules were decreased as compared with the controls. The incidence of dental caries of estrone- or estriol- treated rats was significantly increased in comparison with the controls. The effect of these hormones on the salivary glands and dental caries is identical to that caused by a similar daily injection of 0. 02 mg estradiol benzoate. If these estrogenic hormones are cariogenic in adult humans, it might correlate with the increase in dental caries at the late stage of pregnancy during which stage the 24-hr. urinary output rises (depending on the individual) from 100-1000 times that of normal non-pregnant woman.

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