THE PRODUCTION OF AN ECLAMPSIA-LIKE SYMPTOM-COMPLEX IN RATS BY MEANS OF WATER AND VASOPRESSIN

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Abstract
Neither water intoxication alone nor posterior pituitary extract alone causes characteristic lesions; but a combination of the 2 causes the development of hemorrhages and congestion in brain, liver, kidneys and lungs, similar in appearance to those seen in women with eclampsia. Rats treated in this way also developed edema and convulsions. The most important lesion, is red cell agglutination and resulting infarction, possibily due to cellular rupture, resulting from hyposmolarity of water intoxication, and consequent release of thrombokinase. The resulting increase in plasma fibrinogen causes erythrocyte agglutination and infarction by the agglutinated red cell masses.

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