Reduced cardiac mass by nitrendipine is dissociated from systemic or regional haemodynamic changes in rats

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Abstract
The effects of prolonged treatment (3 weeks) with nitrendipine (10 mg·kg−1 twice daily) on systemic and regional haemodynamics and cardiac mass were studied in SHR and WKY rats. Nitrendipine markedly decreased mean arterial pressure (26.0±0.4 vs 19.9±0.6 kPa, Pvs 0.066±0.004 U·kg−1, P−1·g tissue−1) increased and organ vascular resistances (kPa·ml−1·min−1·100 g tissue−1) decreased significantly (Pvs 7.27±0.31 and 0.04±0.00 vs 0.02±0.00; Pvs 7.98±0.2 and 0.03±0.00 vs 0.02±0.00; Pvs 3.31±0.09; Pvs 2.70±0.06; P<0.01, respectively). Thus, these studies show that nitrendipine, a slow-entry channel calcium blocker, regressed cardiac mass in rats through mechanisms that may be dissociated from their haemodynamic changes.