INVIVO OBSERVATIONS ON THE EFFECT OF CORTISONE ON EXPERIMENTAL TUBERCULOSIS, USING THE RABBIT EAR CHAMBER TECHNIQUE
- 1 January 1952
- journal article
- research article
- Published by Elsevier
- Vol. 65 (1) , 64-74
- https://doi.org/10.1164/art.1952.65.1.64
Abstract
The rabbit ear chamber provides a thin layer of living vascularized tissue 40-50[mu] thick which can be inoculated directly with living virulent tubercle bacilli. The course of infection can be observed in the living animal over a period of weeks and months, and serial microscopic observations can be made on the same tuberclf Cortisone produced a quantitative reduction in the inflammatory response of the hypersensitive rabbit to tuberculous infection. Changes noted were: vascular tone was better maintained, damage to the arteriolar and venule endothelium was reduced, and diapedesis and amt. of exudate were reduced.Keywords
This publication has 5 references indexed in Scilit:
- Response of Tuberculin Skin Test to ACTH and Cortisone in Tuberculous Guinea PigsExperimental Biology and Medicine, 1950
- The effect of cortisone upon the release of histamine during in vitro hemolytic reactions in rabbit bloodJournal of Allergy, 1950
- THE ABILITY OF ACTH AND CORTISONE TO ALTER DELAYED TYPE BACTERIAL HYPERSENSITIVITY1950
- Development of Tuberculous Infection. In vivo Observations in the Rabbit Ear Chamber.Experimental Biology and Medicine, 1948
- The transparent chamber of the rabbit's ear, giving a complete description of improved technic of construction and introduction, and general account of growth and behavior of living cells and tissues as seen with the microscopeJournal of Anatomy, 1928