Two cases of low-renin hypertension thought to be due to excessive secretion of unknown mineralocorticoid.

Abstract
Two patients with low renin hypertension showing an increased urinary excretion with 17-KS [ketosteroid], with a normal level of plasma deoxycorticosterone and no signs of virilization were reported. Dexamethasone induced reduction in blood pressure and elevation of serum K, in spite of acceleration of the renin-angiotensin-aldosterone system. The hypertension probably was not associated with adrenogenital syndrome but was due to excessive production of an unknown mineralocorticoid.

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