Synthesis and biological activity of a new semisynthetic cephalosporin, CN-92,982.
- 1 January 1980
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (11) , 1352-1356
- https://doi.org/10.7164/antibiotics.33.1352
Abstract
A new broad spectrum semisynthetic cephalosporin (CN-92,982) was prepared from the condensation of an acetylaminoacylaminophenyl pyridone with trans-7-[(D-2-phenylglycyl) amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-.DELTA.8-cephem-4-carboxylic acid. The new cephalosporin displayed an in vitro antibacterial spectrum similar to other cephaloglycine types such as cefoperazone and SM-1652. The compound produced a high and prolonged blood level following a single i.m. dose in a dog.This publication has 0 references indexed in Scilit: