Hypertryptophanemia and Indoleketonuria in Two Mentally Subnormal Siblings

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Abstract
To the Editor: Tada1 and Wong2 and their colleagues have described patients with an abnormal response to tryptophan loading, which they ascribed to a defect in the initial conversion of tryptophan to kynurenine. In neither case were the basal plasma levels of tryptophan more than mildly elevated, and indoleic acids were not detected in grossly elevated amounts even after tryptophan loading. We wish to report a new variant of abnormal tryptophan metabolism, characterized by pronounced hypertryptophanemia and tryptophanuria in the absence of tryptophan loading and accompanied by a greatly increased excretion of indoleacetic, indolelactic, and indolepyruvic acids.Our patients, . . .

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