Genetic factors in puerperal affective psychoses

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Abstract
The hypothesis that puerperal affective psychosis (PAP) is genetically relatd to manic-depressive disorder was tested by comparing the morbidity risks for puerperal and non-puerperal affective disorders in the relatives of 17 PAP subjects and 20 parous manic-depressives (PMD) with no history of puerperal illness. The risk for affective disorder (mania, depression or suicide) and puerperal affective disorder was the same in the 2 groups of relatives and the test hypothesis was accepted, although the sample size was small. The frequencies of HLA-A, B and C locus antigens, 9 blood group antigens [ABO, Rh, MNSs, P, KEU, Fy, JDR, Lu, Lewis]and 10 red blood cell isoenzymes [adenosine deaminase, phosphoglucomutase 1 and 2, esterase D, acid phosphatase, adenylate kinase, 6-phosphogluconate dehydrogenase, glucose-6-phosphate dehydrogenase, lactic dehydrogenase, malic dehydrogenase] were not significantly different in the PAP and PMD subjects, showing that in this series genetic markers do not distinguish puerperal from non-puerperal affective psychoses.

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