Cadherin‐dependent cell aggregation is affected by decapeptide derived from rat extracellular super‐oxide dismutase

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Abstract
A synthetic HAV‐containing decapeptide homologous to the amino acid sequence 44R‐Q53 in rat extracellular superoxide dismutase B affects cadherin‐dependent cell aggregation. Cell lines, some of them transfected, expressing different types of cadherins were tested using in vitro cell aggregation and cell dissociation assays. A concentration‐dependent inhibition of aggregation by the EC‐SOD‐derived HAV‐containing peptide was detected only in N‐cadherin expressing cells. These results suggest the localisation and possible protective role of EC‐SOD B for cells expressing N‐cadherin.