Metal-Catalyzed RNA Strand Scission
- 1 January 1991
- journal article
- plenary lectures
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 10 (1-3) , 215-227
- https://doi.org/10.1080/07328319108046448
Abstract
Two novel approaches have been employed for mediating RNA strand scission under physiological conditions. One of these involved strand scission by an Fez+ chelate of the antitumor antibiotic bleomycin; the other involved a novel Mn2+-dependent cleavage of an RNA hairpin at a specific site. Bleomycin-mediated RNA cleavage was oxidative in nature, while the Mn2+-promoted cleavage of the hairpin occurred by a solvolytic mechanism.Keywords
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