Seroepidemiological study of the immune response toCampylobacter pylori in potential risk groups

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Abstract
To gain more understanding of the epidemiology ofCampylobacter pylori infection, the immune response to the organism was studied in the following selected potential risk groups: endoscopy staff (n=45), dental staff (n=58), orphanage children (n=24), psychiatric patients (n=58), and family contacts ofCampylobacter pylori-infected patients (n=55). The frequency of an IgG and IgA antibody response in the different groups was determined by the immunoblot method and compared with that in an appropriate control group (n=189). The frequency of a positive antibody response was dependent on age (pCampylobacter pylori-infected patients and people living in closed communities such as psychiatric patients and orphanage children must be considered as risk groups forCampylobacter pylori infection. The findings support the notion that person-to-person spread and a common source are the predominant modes of transmission ofCampylobacter pylori in addition to endoscopes.