Synthesis and Antimalarial Activities of Several Fluorinated Artemisinin Derivatives
- 1 September 1995
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 38 (20) , 4120-4124
- https://doi.org/10.1021/jm00020a028
Abstract
The carbonyl groups in several artemisinin derivatives were converted into geminal difluorinated compounds on treatment with diethylaminosulfur trifluoride. A number of other mono- and polyfluorinated artemisinin derivatives were prepared. Their in vitro antimalarial activities were all equal to or greater than the nonfluorinated analogs or precursors.Keywords
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