A New Model for Toxic Risk Assessments: Construction of Homozygous Rapid and Slow Acetylator Congenic Syrian Hamster Lines

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Abstract
Summary: Humans and other mammals exhibit a polymorphic expression for acetylation capacity that can confer genetic predisposition to drug and chemical toxicities. Inbred Syrian hamsters are a particularly suitable animal model for the human trait, in part because of a clearly defined codominant expression of two alleles (r, rapid acetylator; s, slow acetylator) at a single gene (Pat) locus. Homozygous rapid (Patr/Patr), heterozygous intermediate (Patr/Pats), and homozygous slow (Pats/Pats) acetylator congenic Syrian hamster lines were constructed by a selective backcross method. The construction of these congenic inbred lines will enhance efforts to investigate the unique role of the acetylator gene locus in toxic risk assessments of arylamine xenobiotics.