Further synthesis of enkephalinol analogs containing the dipeptide unit Tyr-Arg (kyotorphin).
- 1 January 1982
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 30 (7) , 2447-2452
- https://doi.org/10.1248/cpb.30.2447
Abstract
In order to obtain enkephalin derivatives with high analgesic activity, four enkephalinol analogs having the Tyr-D-Arg unit in the N-terminal position were synthesized. Of these, H-Tyr-D-Arg-Gly-MePhe-Met (O)-ol exhibited analgesic activity comparable to that of morphine after intravenous administration to mice.Keywords
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