Long‐lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10‐year prospective study
Top Cited Papers
- 12 February 2003
- journal article
- clinical trial
- Published by Wiley in Clinical and Experimental Allergy
- Vol. 33 (2) , 206-210
- https://doi.org/10.1046/j.1365-2222.2003.01587.x
Abstract
Summary: Background Subcutaneous immunotherapy for respiratory allergy has shown a long‐lasting efficacy after its discontinuation, whereas this evidence is still lacking for sublingual immunotherapy, despite the fact that it is widely used.Objective We aimed to evaluate whether a long‐lasting effect of SLIT occurs, in a prospective parallel group controlled study.Methods Sixty children (mean age 8.5 years) suffering from allergic asthma/rhinitis due to mites were subdivided into two matched groups: 35 underwent a 4‐ to 5‐year course of SLIT with standardized extract and 25 received only drug therapy. The patients were evaluated at three time points (baseline, end of SLIT and 4 to 5 years after SLIT discontinuation) regarding presence of asthma, use of anti‐asthma drugs, skin prick tests and specific IgE.Results We found that in the SLIT group there was a significant difference vs. baseline for the presence of asthma (P ≤ 0.001) and the use of asthma medications (P ≤ 0.01), whereas no difference was observed in the control group. The mean peak expiratory flow result was significantly higher in the active group than in the control group after 10 years. No change was seen as far as new sensitizations were concerned. Specific IgE showed a near‐significant increase (baseline vs. 10 years, P = 0.06) only in the control group.Conclusion Our study demonstrates that sublingual immunotherapy is effective in children and that it maintains the clinical efficacy for 4 to 5 years after discontinuation.Keywords
This publication has 26 references indexed in Scilit:
- Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study)Journal of Allergy and Clinical Immunology, 2002
- Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six‐year follow‐up study.Clinical and Experimental Allergy, 2001
- Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective studyClinical and Experimental Allergy, 2001
- Long‐term treatment with allergoid immunotherapy with Parietaria. Clinical and immunologic effects in a randomized, controlled trialAllergy, 1999
- The kinetics of change in cytokine production by CD4+ T cells during conventional allergen immunotherapyJournal of Allergy and Clinical Immunology, 1999
- Immunotherapy with a standardized extract. VI. Specific immunotherapy prevents the onset of new sensitizations in childrenJournal of Allergy and Clinical Immunology, 1997
- Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy☆☆☆★★★Journal of Allergy and Clinical Immunology, 1997
- Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-γJournal of Allergy and Clinical Immunology, 1996
- Long-term follow-up of patients treated with a three-year course of cat or dog immunotherapyJournal of Allergy and Clinical Immunology, 1995
- Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.Journal of Clinical Investigation, 1993