HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.
- 15 October 1991
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 88 (20) , 8900-8904
- https://doi.org/10.1073/pnas.88.20.8900
Abstract
A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.Keywords
This publication has 37 references indexed in Scilit:
- Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with MycScience, 1991
- Molecular characterization of the t(10;14) translocation breakpoints in T‐cell acute lymphoblastic leukemia: Further evidence for illegitimate physiological recombinationGenes, Chromosomes and Cancer, 1990
- An update of mouse and human HOX gene nomenclatureGenomics, 1990
- Variations of cervical vertebrate after expression of a Hox-1.1 transgene in micePublished by Elsevier ,1990
- Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding ProteinsScience, 1989
- The structure and function of the homeodomainBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1989
- lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motifCell, 1989
- Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the β T cell receptor gene in human lymphoblastic neoplasmsCell, 1987
- Nomenclature for homoeobox-containing genesNature, 1987
- Diversity and rearrangement of the human T cell rearranging γ genes: Nine germ-line variable genes belonging to two subgroupsCell, 1986