ROLE OF ACETALDEHYDE IN THE INDUCTION OF HEART LEFT VENTRICULAR ATRIAL NATRIURETIC PEPTIDE GENE EXPRESSION IN RATS

Open Access

1 July 2000

journal article
research article
Published by Oxford University Press (OUP) in Alcohol and Alcoholism

Vol. 35 (4) , 331-335
https://doi.org/10.1093/alcalc/35.4.331

Abstract

We studied the effects of ethanol and acetaldehyde on myocardial gene expression of atrial natriuretic peptide (ANP) and growth of rats. Combined ethanol and calcium carbimide treatment increased blood-acetaldehyde levels and ANP mRNA levels by 40–60% in 2–8 day experiments, compared to the controls. The results suggest a role for acetaldehyde in the development of alcoholic heart dysfunction.

Keywords

GENE EXPRESSION
TREATMENT
HEART
INDUCTION
ACETALDEHYDE
DYSFUNCTION
ALCOHOLIC
MYOCARDIAL
ATRIAL
CARBIMIDE

This publication has 0 references indexed in Scilit: