Inhibitors of HIV-1 Protease
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Journal of Enzyme Inhibition
- Vol. 6 (1) , 65-98
- https://doi.org/10.3109/14756369209041357
Abstract
The human immunodeficiency virus (HIV), the etiological agent for the acquired immune deficiency syndrome (AIDS), is a retrovirus which makes use of a virally-encoded aspartic protease to perform specific proteolytic processing of two of its gene products in order to form active enzymes and structural proteins within the mature virion. Accordingly, specific, exogenous inhibition of the HIV-1 protease is thought to be a viable approach for the developmenit of novel therapeutics for the treatment of AIDS. Indeed, this hypothesis has been validated in virally-infected cell culture with synthetic inhibitors of HIV-1 protease. This chapter reviews the current status of the development of inhibitors of this enzyme.Keywords
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