HAIRPIN-TAIL: A CASE OF POST-REDUCTIONAL GENE ACTION IN THE MOUSE EGG?
Open Access
- 1 April 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 76 (4) , 795-805
- https://doi.org/10.1093/genetics/76.4.795
Abstract
Hairpin-tail (Thp) is a new allele of brachyury on chromosome 17 (linkage group IX) of the mouse. The morphological effects in the heterozygote are on the notochord and the tail. The homozygous abnormal is unknown. Thp is unique in that the phenotype of the heterozygote seems to depend on the source of the Thp gene. If it is inherited via the egg the phenotype is extreme and death follows in utero. Embryos derived from a Thp sperm and a+egg are less abnormal and viable. This is not a simple maternal effect, as Thp×Thp matings produce two distinct types of heterozygous embryos.Keywords
This publication has 2 references indexed in Scilit:
- Curtailed, a new dominant T-allele in the house mouseGenetics Research, 1966
- Investigations of the nature of t-alleles in the mouseHeredity, 1964