ALKALINE-PHOSPHATASE, LEUCINE AMINOPEPTIDASE, AND ALANINE AMINOTRANSFERASE ACTIVITIES WITH OBSTRUCTIVE AND TOXIC HEPATIC DISEASE IN CATS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 38  (7) , 963-967
Abstract
The activities of serum alkaline phosphatase (serum ALP), leucine aminopeptidase (serum LAP) and alanine aminotransferase (serum ALT) were determined in 15 cats before and after treatment by 3 methods: common bile duct occlusion, left hepatic duct(s) occlusion and CCl4 administration. Significant increases in serum ALP, LAP and ALT activities occurred in all cats in the 3 groups. Sustained mean increases of 9-fold in ALP and 13-fold in LIP occurred in the cats with common bile duct occlusion. Lesser mean increases of these enzymes (4-fold) occurred in the cats with partial biliary occlusion. Transient mean increases (100-fold) in ALT occurred in the CCl4-treated cats. Urine ALP excretion was measured in 3 cats with common bile duct occlusion. There was no significant difference between rates of urine ALP excretion before and after common bile duct occlusion. Specific ALP activities of hepatic extracts from normal cats and biliary-obstructed cats were compared. Mean specific activity was 1-fold higher in liver from cats with common bile duct occlusion of 21 days'' duration. Serum ALP and LAP are useful to detect biliary occlusive disease in cats and in conjunction with serum ALT may be used to differentiate primary hepatodegenerative disease and biliary occlusive disease.

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