The ser9gly SNP in the dopamine D3 receptor causes a shift from cAMP related to PGE2 related signal transduction mechanisms in transfected CHO cells
Open Access
- 1 November 2004
- journal article
- letter
- Published by BMJ in Journal of Medical Genetics
- Vol. 41 (11) , 867-871
- https://doi.org/10.1136/jmg.2004.020941
Abstract
Dopamine enhances basal and stimulus evoked release of arachidonic acid, as well as the production of one of its metabolites, prostaglandin E2 (PGE2), in CHO (Chinese hamster ovary) cells transfected with the D2 receptor.4– 6 In contrast, dopamine does not influence basal arachidonic acid release7– 9 but inhibits stimulus evoked release in cells transfected with the rat D3 receptor.10 On the other hand, with respect to cAMP production, the effect of dopamine is similar in CHO cells transfected with either D2 or D3 receptors, both receptor subtypes mediating a reduction in forskolin induced cAMP formation.11, 12Keywords
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