Transfer hydrogenation; a convenient method for removal of some commonly used protecting groups in peptide synthesis
- 1 January 1977
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 5,p. 490-491
- https://doi.org/10.1039/p19770000490
Abstract
N-Benzyloxycarbonyl and benzyl ester groups in peptides can be conveniently removed by transfer hydrogenation with cyclohexene and 10% palladium–carbon catalyst. If freshly prepared palladium black catalyst is used, other commonly used protecting groups like Nτ-benzyl (histidine), benzyl ether (tyrosine, serine), and nitro (arginine) can also be removed much more rapidly than in the case of the usually employed catalytic hydrogenation.This publication has 0 references indexed in Scilit: