Ovarian Tumor Types and Their Incidence in Intact Mice Following Whole-Body Exposure to Ionizing Radiation

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Abstract
Over 3100 young adult female RF/Un mice were given 0-400 rads of whole-body irradiation with 60-MeV protons or 300-kVp X-rays in single doses at a dose rate of 80-100 rad/min. Only slight differences in ovarian tumor induction existed between types of radiation. Untreated mice developed 3.8% ovarian tumors, 50-60% incidence was seen after 50-100 rads and a gradual decline in incidence was observed from 100-400 rads. Tumor cell types (primarily luteal cell, granulosa cell and tubular adenoma) were identified histologically in 2400 mice, and tumors were characterized as single cell or mixed cell type. From 0-100 rads relative proportions of mixed cell tumors increased and single cell tumors decreased. They were about equal from 100-400 rads. Approximately 90% of the ovarian tumors at 50 rads contained tubular adenoma elements. This decreased to 70% at 400 rads. Luteomas increased to 40% at 50 rads and 60% at 100 rads and showed no dose effect from 100-400 rads. Granulosa cell tumors showed no dose effect, remaining at an incidence of 15-20% from 50-400 rads. A comparison of the difference between control values and the incidence of various cell types at the lowest dose (50 rad) showed that tubular adenomatous tumors were most common, luteal were intermediate and granulosa cell were lowest in occurrence. These results suggest a relative radiosensitivity of these ovarian tissues for tumor production in the intact animal conditions used in this study.