Chlorambucil for Childhood Nephrosis

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Abstract
The term minimal-change glomerulopathy applies to the renal histology noted in the majority of children with the idiopathic nephrotic syndrome. Almost no change in glomerular morphology is found, but there is a subtle ultrastructural alteration in the epithelial cells that is referred to as "foot-process fusion." The virtual absence of histopathologic abnormalities is in striking contrast to the functional breakdown in the selective-permeability barrier of the glomerular capillary wall. The glomerular albumin leak causes profound hypoalbuminemia and hypovolemia with consequent renal retention of salt and water. Little is known of the cause of this lesion, and therapeutic approaches to the . . .