Chemical conversion of gardnerine into koumidine by inverting the ethylidene side chain with palladium catalyst.

1 January 1989

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 37 (8) , 2256-2257
https://doi.org/10.1248/cpb.37.2256

Abstract

A minor Gelsemium alkaloid, koumidine (1), was synthesized from gardnerine (2) by the demethoxylating the indole ring and the inverting the configuration of the ethylidene side chain with palladium catalyst.

Keywords

CONVERSION
MINOR
KOUMIDINE
GARDNERINE
CHAIN WITH PALLADIUM
ETHYLIDENE SIDE CHAIN

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