Disorganization of Microfilaments Is Accompanied by Downregulation of α-Smooth Muscle Actin Isoform mRNA Level in Cultured Vascular Smooth Muscle Cells
- 1 July 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 112 (1) , 102-106
- https://doi.org/10.1093/oxfordjournals.jbchem.a123845
Abstract
In the previous report, we demonstrated that cAMP negatively regulated α-smooth muscle actin mRNA levels through destabilization of the mRNA [O. Ohara et al. (1901) J. Biochem. 109, 834–839]. We here report that the decline in the α-smooth muscle actin mRNA levels was well correlated with disorganization of microfilaments but not necessarily with the rise in intracellular cAMP levels in rat cultured vascular smooth muscle cells. The decrease in the α-smooth muscle actin mRNA induced by microfilament-disorganizing agents also resulted from enhancement of the turnover rate of the mRNA. These results raise the possibility that the post-transcriptional control of the α-smooth muscle actin expression is linked to the organization of actin filaments in smooth muscle cells.Keywords
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