Four deaths and a funeral: from caspases to alternative mechanisms
Top Cited Papers
- 1 August 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 2 (8) , 589-598
- https://doi.org/10.1038/35085008
Abstract
A single family of proteases, the caspases, has long been considered the pivotal executioner of all programmed cell death. However, recent findings of evolutionarily conserved, caspase-independent controlled death mechanisms have opened new perspectives on the biology of cell demise, with particular implications for neurobiology, cancer research and immunological processes.Keywords
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