Experimental Malignant Tumors From Retinal Pigment Epithelium
- 1 July 1972
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 88 (1) , 70-74
- https://doi.org/10.1001/archopht.1972.01000030072015
Abstract
Malignant neoplasms of the retinal pigment epithelium (RPE) were produced by infecting pure cultures of hamster RPE in vitro with simian vacuolating virus 40, an oncogenic DNA virus. When transformed cells were injected subcutaneously into irradiated 4-week-old hamsters, neoplasms developed at the injection site within three weeks and subsequently killed the animals by generalized metastasis. These experimental tumors resembled morphologically some tumors seen in human eyes arising from the RPE. While extraocular invasion or metastasis of human RPE tumors has not been documented convincingly, this study demonstrates that under experimental conditions retinal pigment can give rise to tumors capable of invasion and metastasis and provides a model useful in distinguishing histologic characteristics of true malignant tumors of the RPE.Keywords
This publication has 2 references indexed in Scilit:
- In Vitro Growth of Pure Cultures of Retinal Pigment EpitheliumArchives of Ophthalmology (1950), 1972
- Infection of chick iris epithelium with the Rous sarcoma virus in vitroVirology, 1960