Glucostat Capacity and Metabolie Zonation in Rat Liver after Portocaval Anastomosis

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Abstract
The activities and zonal distribution of key enzymes of carbohydrate metabolism were studied in rats after end-to-side portacaval anastomosis. Sham-operated controls with the same periods of hepatic blood supply interruption as the shunted animals were pair-fed. Food uptake, body weight and liver weight alterations were monitored. Total liver glycogen reserves were reduced. Enzyme activities were monitored in glucogenic phosphoenolpyruvate kinase and glucose-6-phosphatase, glycolytic pyruvate kinase isozyme L and glucokinase, and the citric acid cycle enzyme succinate dehydrogenase. The observed changes indicate that after portocaval anastomosis the reduction of liver metabolic capacity was more pronounced with glycolysis than gluconeogenesis. The relative gluconeogenic capacity of the periportal zone increased while the glycolytic capacity of the perivenous zone decreased. The glucostat function of the organ was slightly impaired but not lost.

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