Suppression of Vasomotor Reflexes in Man Following L-Hydrazinophthalozine (C-5968).

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Abstract
C-5968 admd. intraven. in doses of 0.3-0.35 mg./kg. in man resulted in partial to complete suppression of the vaso-pressor response following the Valsalva maneuver, the tiltback "overshoot," and the cold pressor response. Reflex vasoconstrictor responses to "noxious" stimuli in the digits were significantly inhibited. Epinephrine reversal did not occur. Norepinephrine bradycardia was more completely blocked than norepinephrine hypertension. Nasal congestion and impairment of pupillary accommodation were not observed following C-5968. Palpitation and tachycardia frequently occurred. Although suppression of vasomotor reflexes was demonstrated the site of action could not be detd. from these studies.

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