Chemokine Mutation Slows Progression
- 16 January 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 279 (5349) , 327
- https://doi.org/10.1126/science.279.5349.327
Abstract
Why HIV takes so long to destroy the immune system is a central question in AIDS research. Now, findings presented in this issue may provide fresh clues to the mystery--as well as suggest new therapies that could slow or stop progression of the disease. On page 389, a team of geneticists reports that HIV-infected patients who have a mutant gene for a chemokine called SDF-1 progress much more slowly to full-blown AIDS or death than do people with a normal version of the gene. These findings mark the first time that a mutation in a gene coding for a chemokine, rather than a chemokine receptor, has been shown to affect the course of HIV infection.This publication has 0 references indexed in Scilit: