Donor age‐related differences in PBPC mobilization with rHuG–CSF
- 1 February 2001
- journal article
- research article
- Published by Wiley in Transfusion
- Vol. 41 (2) , 201-205
- https://doi.org/10.1046/j.1537-2995.2001.41020201.x
Abstract
BACKGROUND: Data on the administration of rHuG–CSF to normal donors 6 per kg of donor′s body weight in Group A and B, respectively. Fifty‐six percent of Group A donors needed only one apheresis to achieve ≥4 × 106 CD34+ cells per kg versus 39 percent of Group B donors (p = 0.01). Side effects were more common in Group B (71% vs. 41%; p<0.001). CONCLUSION: The administration of rHuG–CSF to donors <18 years old leads to CD34+ cell mobilization in a pattern similar to that observed in adults. Greater age was associated with a more frequent requirement for more than one apheresis to achieve a similar number of CD34+ cells.Keywords
This publication has 18 references indexed in Scilit:
- Peripheral blood stem cell mobilization and apheresis: analysis of adverse events in 94 normal donorsBone Marrow Transplantation, 1999
- Administration of recombinant human granulocyte colony-stimulating factor to normal donors: results of the Spanish National Donor RegistryBone Marrow Transplantation, 1999
- Blood and marrow transplantation activity in Europe 1997Bone Marrow Transplantation, 1999
- Peripheral blood progenitor cell (PBPC) collection by large-volume leukapheresis from pediatric donorsBone Marrow Transplantation, 1999
- Not All Healthy Donors Mobilize Hematopoietic Progenitor Cells Sufficiently After G-CSF Administration to Allow for Subsequent CD34 Purification of the Leukapheresis ProductJournal of Hematotherapy, 1998
- Treatment of normal individuals with granulocyte‐colony‐stimulating factor: donor experiences and the effects on peripheral blood CD34+ cell counts and on the collection of peripheral blood stem cellsTransfusion, 1996
- Clinical toxicity and laboratory effects of granulocyte‐colony‐ stimulating factor (filgrastim) mobilization and blood stem cell apheresis from normal donors, and analysis of charges for the proceduresTransfusion, 1996
- THE PLACE OF BLOOD STEM CELLS IN ALLOGENEIC TRANSPLANTATIONBritish Journal of Haematology, 1996
- Haematological study of healthy volunteers 5 years after G-CSFThe Lancet, 1995
- G‐CSF‐mobilized peripheral blood progenitor cells for allogeneic transplantation: safety, kinetics of mobilization, and composition of the graftBritish Journal of Haematology, 1994