The Cause of Persisting Hypercholesteremia in Rabbit after Cessation of Cholesterol Feeding.

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Abstract
Normal rabbits received either chylomicronous serum from cholesterol fed rabbits or clear hypercholesteremic serum from bile acid injected rats. The injected cholesterol disappeared from the recipient''s serum with equal rapidity in either case. By exchange transfusion with normal animals, the plasma cholesterol of rabbits with residual hypercholesteremia persisting 40 days after cessation of cholesterol feeding was acutely reduced. It was observed to rise to pre-reduction levels within the following 5 days. When the plasma cholesterol of normal rabbits was acutely raised by exchange transfusion with hypercholesteremic plasma, it promptly fell to normal levels within 3 days. The authors interpret these facts to mean that chronic discharge of cholesterol from tissue stores is responsible for the long persistent hypercholesteremia in the rabbit after feeding.

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