Animal Experiments with Chemically Treated Fibres

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Abstract
After intraperitoneal injection of 25 mg HC1-leached chrysotile into rats acute toxic effects were observed. Protein might dissolve the amorphous silicic acid of the leached fibres; this also prevents the tumour induction by doses which are not acutely toxic. The carcinogenicity of very resistant glass fibres was not influenced by HC1 and NaOH. The carcinogenic effect of another specimen was strongly reduced by HC1; this treatment did not change the shape of the glass fibres; however, the durability in the lung decreased. 0.3 mg actinolite induced tumours in the abdominal cavity in 83% of the intraperitoneally injected rats. The carcinogenicity decreased to 7% when actinolite was injected in a solution of polyvinylpyridine-N-oxide (PVNO). Application of PVNO separately from chrysotile or actinolite had no significant effect.

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