Cleavage and deprotection of peptides on MBHA‐resin with hydrogen bromide
- 1 September 1992
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 40 (3-4) , 344-349
- https://doi.org/10.1111/j.1399-3011.1992.tb00310.x
Abstract
Dilute hydrogen bromide in trifluoroacetic acid containing pentamethylbenzene and thioanisole was used in the cleavage and deprotection of peptides on MBHA-resin. Particular attention was paid to potential applicability of the method to kilogram scale synthesis of thymosin alpha 1. In the HPLC purification of the peptides, acetonitrile was replaced by relatively nontoxic isopropanol. The change should be economically and environmentally very attractive.Keywords
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