Methotrexate and asparaginase combination chemotherapy in refractory acute lymphoblastic leukemia of childhood
- 1 March 1979
- Vol. 43 (3) , 1089-1094
- https://doi.org/10.1002/1097-0142(197903)43:3<1089::aid-cncr2820430346>3.0.co;2-h
Abstract
Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3 partial remissions, and 5 failures. Responsiveness to Asn'ase seemed necessary for successful induction with the drug combination. Maintenance therapy in 18 children produced a median hematologic remission of 31 weeks (range 3–85 weeks). During remission, 2 children developed central nervous system leukemia and 2 died of infection. The mean maximally tolerated dose of MTX was 361 mg/m2. The results of this trial suggest therapeutic synergy in maintenance therapy and the capability of Asn'ase to attenuate MTX toxicity. Cancer 43:1089–1094, 1979.Keywords
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