Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients
Open Access
- 27 July 2005
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 118 (2) , 284-289
- https://doi.org/10.1002/ijc.21358
Abstract
No abstract availableKeywords
This publication has 20 references indexed in Scilit:
- HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cellsOncogene, 2003
- Akt kinases in breast cancer and the results of adjuvant therapyBreast Cancer Research, 2003
- The protein kinase B/Akt signalling pathway in human malignancyCellular Signalling, 2002
- NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancerThe EMBO Journal, 2000
- HER-2/neu Blocks Tumor Necrosis Factor-induced Apoptosis via the Akt/NF-κB PathwayJournal of Biological Chemistry, 2000
- Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancerThe EMBO Journal, 1999
- The role of ErbB-2 tyrosine kinase receptor in cellular intrinsic chemoresistance: mechanisms and implicationsBiochemistry and Cell Biology, 1997
- c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodesBritish Journal of Cancer, 1991
- Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian CancerScience, 1989
- Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu OncogeneScience, 1987