Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.
Open Access
- 1 February 1991
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 173 (2) , 507-510
- https://doi.org/10.1084/jem.173.2.507
Abstract
We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL-10). It was found that IL-10 alone failed to support the growth of mast cell lines and mast cell progenitors. Nevertheless, it dramatically enhanced their growth when combined with IL-3 or IL-4. Moreover, IL-4 plus IL-10 supported the proliferation of mast cells as well as IL-3, suggesting that these two factors may provide a pathway for their development independent of IL-3. However, optimal mast cell growth was stimulated by the combination of IL-10, IL-4, and IL-3. This particular set of cytokines are coordinately produced by activated T cells and may constitute an effective network regulating early and late stages of mast cell development during certain immune responses.Keywords
This publication has 9 references indexed in Scilit:
- Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.The Journal of Experimental Medicine, 1990
- Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10International Immunology, 1990
- Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFIScience, 1990
- Mast cell growth‐enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9)European Journal of Immunology, 1990
- INTERLEUKIN-6 INTERACTS WITH INTERLEUKIN-4 AND OTHER HEMATOPOIETIC GROWTH-FACTORS TO SELECTIVELY ENHANCE THE GROWTH OF MEGAKARYOCYTIC, ERYTHROID, MYELOID, AND MULTIPOTENTIAL PROGENITOR CELLS1989
- Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells.Proceedings of the National Academy of Sciences, 1987
- Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.Proceedings of the National Academy of Sciences, 1986
- Characterization of a murine lymphokine distinct from interleukin 2 and interleukin 3 (IL-3) possessing a T-cell growth factor activity and a mast-cell growth factor activity that synergizes with IL-3.Proceedings of the National Academy of Sciences, 1986
- A cloned MCGF cDNA encodes a multilineage hematopoietic growth factor: multiple activities of interleukin 3.The Journal of Immunology, 1985