Experimental Production of Various Renal-vascular Disorders

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Abstract
Previous expts., on exptl. production of different renal vascular disorders are discussed. Clamping of both kidneys for 1 or 2 hrs. proved fatal for the rat but was unimportant for the avg. dog and could be repeated at intervals of a few days over a long period without causing uremia. Clamping for 6-8 hrs. proved fatal to dogs; the death was not actually uremic: When one kidney was clamped for 4 or 5 hrs. and then, after a lapse of several days, the other kidney was similarly clamped, uremia, without an increase in blood pressure, resulted. The author believes that every dog will develop hypertension if it survives the necessary number of clampings of proper duration, but the majority succumb because of uremia. Some dogs with explanted kidneys after repeated clampings developed an epileptiform state. Clamping of the pancreatic vessels produced diabetes.

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