3,4-Dihydropyrimidin-2(1H)-Ones: Fast Synthesis Under Microwave Irradiation in Solvent Free Conditions
- 1 January 2000
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 30 (12) , 2165-2173
- https://doi.org/10.1080/00397910008087395
Abstract
Microwave irradiation has been used to accelerate the synthesis of the Biginelli compounds, in one-pot reaction between β-keto esters, aryl aldehydes, and urea. These solvent-free reactions show that it is possible to prepare these compounds in a short time reaction and with good yield and easily isolable.Keywords
This publication has 13 references indexed in Scilit:
- New Solvent-Free Organic Synthesis Using Focused MicrowavesSynthesis, 1998
- A solid phase protocol of the biginelli dihydropyrimidine synthesis suitable for combinatorial chemistryTetrahedron Letters, 1995
- Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agentsJournal of Medicinal Chemistry, 1992
- Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agentsJournal of Medicinal Chemistry, 1991
- Dihydropyrimidine calcium channel blockers. II. 3-Substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridinesJournal of Medicinal Chemistry, 1990
- 1,4-Cycloaddition of 1,3-diazabutadienes with enamines: An efficient route to the pyrimidine ringTetrahedron Letters, 1989
- Substituted 1,4-dihydropyrimidines. 3. Synthesis of selectively functionalized 2-hetero-1,4-dihydropyrimidinesThe Journal of Organic Chemistry, 1989
- Synthesis of Substituted 1,2,3,4-Tetrahydro-6-methyl-2-thioxo-5-pyrimidinecarboxylic Acid EstersHETEROCYCLES, 1987
- The use of microwave ovens for rapid organic synthesisTetrahedron Letters, 1986
- Simple and regioselective synthesis of N-substituted pyrimidine-2(1H)-ones and -thionesJournal of the Chemical Society, Chemical Communications, 1979