Studies on human N-acetyl-β-d-hexosaminidase C separated from neonatal brain
- 1 April 1976
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 155 (1) , 205-208
- https://doi.org/10.1042/bj1550205
Abstract
Human brain hexosaminidase C was separated from isoenzymes A and B by Sephadex G-200 gel filtration. Properties of the enzyme were studied, particularly its isoelectric-focusing profile, pI4.80. These findings indicate that hexosaminidase C is identical with the major residual component of Sandhoff fibroblasts with respect to substrate specificity, pI and activity pH optimum.This publication has 20 references indexed in Scilit:
- Hexosaminidase C in Tay-Sachs and sandhoff diseaseBiochimica et Biophysica Acta (BBA) - Enzymology, 1975
- Tay-Sachs and Sandhoff's disease: Intergenic complementation after somatic cell hybridizationExperimental Cell Research, 1974
- Differences between the N‐acetyl hexosaminidase isozymes in serum and tissuesAnnals of Human Genetics, 1974
- Electrophoretic study of hexosaminidases. Hexosaminidase CClinica Chimica Acta; International Journal of Clinical Chemistry, 1973
- Cystic fibrosis and liver β-galactosidase and β-glucosidaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1972
- Separation and characterisation of N-acetyl-β-glucosaminidases A and P from maternal serumBiochimica et Biophysica Acta (BBA) - Protein Structure, 1972
- The demonstration of multiple heat stable forms of N-acetyl-β-glucosaminidase in normal human serumBiochimica et Biophysica Acta (BBA) - Protein Structure, 1972
- A simple apparatus for rapid isoelectrofocusing of multiple samples on a micro scaleAnalytical Biochemistry, 1970
- Tay-Sachs Disease: Generalized Absence of a Beta-D- N -Acetylhexosaminidase ComponentScience, 1969
- Deficient hexosaminidase activity in an exceptional case of Tay-Sachs disease with additional storage of kidney globoside in visceral organsLife Sciences, 1968