Effect of 2-Nicotinamidethyl Nitrate (SG 75) on Coronary Circulation

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Abstract
The effect of a new chemical agent, SG 75 on coronary blood flow of anesthetized dogs was examined. Administrations i.v. in a dose of 10 .mu.g/kg or over caused a significant increase in blood flow of non-constricted coronary artery. Increases in flow were 40% (10 .mu.g/kg), 95% (50 .mu.g/kg), 145% (100 .mu.g/kg) and 195% (250 .mu.g/kg). Increases were significantly larger than those caused by the same doses of diltiazem, verapamil, nitroglycerin, isosorbide dinitrate and papaverine. Durations of the increase in flow were 12 (10 .mu.g/kg), 23 (50 .mu.g/kg), 28 (100 .mu.g/kg) and 46 min (250 .mu.g/kg), and were longer than those caused by diltiazem and verapamil. A slight reduction in left ventricular tension and an increase in aortic blood flow were also observed following the administrations of SG 75 in a dose of over 50 .mu.g/kg. A decrease in heart rate was produced with a dose of over 500 .mu.g/kg. PQ interval of ECG became shorter. Administrations i.v. of SG 75 in doses of 50 and 150 .mu.g/kg caused an increase in blood flow of the constricted coronary artery, while nitroglycerin (10 and 30 .mu.g/kg) and nifedipine (1 and 3 .mu.g/kg) reduced flow. Results indicate that SG 75 is a potent and long-acting coronary vasodilating agent and causes an increase in blood flow of constricted as well as non-constricted coronary artery.

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