3‐Hydroxyacyl‐CoA epimerase is a peroxisomal enzyme and therefore not involved in mitochondrial fatty acid oxidation

Open Access

3 June 1985

journal article
Published by Wiley in FEBS Letters

Vol. 185 (1) , 129-134
https://doi.org/10.1016/0014-5793(85)80755-9

Abstract

The subcellular location of 3‐hydroxyacyl‐CoA epimerase (EC 5.1.2.3) was studied by differential centrifugation and Percoll density gradient centrifugation of a rat liver homogenate. The enzyme was found to be associated with peroxisomes but not with mitochondria. This observation proves that 3‐hydroxy‐acyl‐CoA epimerase does not function in mitochondrial β‐oxidation ofpolyunsaturated fatty acids which are degraded by a modified pathway.

Keywords

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