Characterization of Immunoregulatory T Cells in EBV-Induced Infectious Mononucleosis by Monoclonal Antibodies

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Abstract
IN infectious mononucleosis induced by Epstein–Barr virus (EBV), an initial viral infection of B lymphocytes1 is usually followed by an extensive proliferation of T cells.2 , 3 In functional studies these T cells are cytotoxic against EBV-infected lymphoid cells4 , 5 and inhibit their outgrowth.6 In addition, they suppress autologous T-cell proliferation to antigens as well as B-cell immunoglobulin production stimulated by pokeweed mitogen.7 , 8 They are thought to be of major importance in the self-limiting aspect of the disease.Maturation and differentiation of T-lymphoid cells into lymphocyte subsets with particular immunologic functions is expressed by distinctive patterns of cell-surface antigens.9 Recently, monoclonal antibodies directed . . .